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Renal impairment in patients with ovarian cancer
Carlo Donadio1, Annalisa Lucchesi, Michela Ardini
1Department of Internal Medicine, Division of Nephrology, University of Pisa, I-56100, Pisa, Italy. cd.donadio@med.unipi.it
Objective:
To investigate the prevalence of renal impairment in patients with ovarian cancer at the time of the diagnosis.
Study Design:
Creatinine clearance was estimated according to Cockcroft and Gault (C&G Ccr), glomerular filtration rate (GFR) was determined as renal clearance of 99mTc-DTPA, and renal ultrasound was performed in 60 consecutive patients with newly diagnosed ovarian cancer.
Results:
A 28% of the total population studied had a GFR <60 ml/min/1.73 m(2). A moderate/severe dilation of the upper urinary tract was found in 12% of patients. The length of kidneys ranged between 9.0 and 13.5 cm, and a statistically significant correlation was found between kidney length and values of GFR.
Conclusion:
A reduction in renal function and a moderate to severe dilation of upper urinary tract frequently occur in patients with ovarian cancer at the time of the diagnosis.