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Depomedroxyprogesterone acetate for hot flashes.

Debra Barton¹, Charles Loprinzi, Susan Quella

¹Mayo Clinic, Rochester, MN 55905, USA.

Journal of Pain and Symptom Management

|January 29, 2003

Summary

This summary is machine-generated.

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Depomedroxyprogesterone acetate injections significantly reduced hot flashes by about 90% in men and women undergoing cancer therapy. This treatment was well-tolerated and provided lasting relief from problematic hot flashes.

Area of Science:

Oncology
Endocrinology
Pharmacology

Background:

Hot flashes are a common side effect of androgen deprivation therapy for prostate cancer and a symptom in women with a history of breast cancer.
Managing hot flashes is crucial for improving patient quality of life during cancer treatment.

Purpose of the Study:

To evaluate the efficacy and tolerability of long-acting medroxyprogesterone acetate for managing hot flashes in patients undergoing cancer therapy.

Main Methods:

A clinical practice study involving 18 patients (3 men with prostate cancer, 15 women with breast cancer history).
Patients received three biweekly intramuscular injections of 500 mg depomedroxyprogesterone.
Effectiveness and tolerability were assessed through hot flash diaries and patient chart reviews.

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Main Results:

Treatment resulted in an approximate 90% decrease in hot flashes.
Mean daily hot flash frequency reduced from 10.9 to 0.7 within 12 weeks.
Symptomatic improvement persisted for months after treatment cessation in many patients.
Reported side effects were minimal, indicating good tolerability.

Conclusions:

Long-acting medroxyprogesterone acetate appears to be an effective and well-tolerated treatment option for managing hot flashes in patients undergoing cancer therapy.
Further research may be warranted to confirm these findings in larger, controlled trials.