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Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian
Bianca R Mothé1, Jason Weinfurter, Chenxi Wang
1Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715-1299, USA.
Journal of Virology
|January 29, 2003
Abstract:
Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIV(mac)239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.