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[Technology and analysis of Ginkgo tincture]
Jurga Bernatoniene1, Arūnas Savickas, Faustas Malinauskas
1Faculty of Pharmacy, Kaunas University of Medicine, A. Mickeviciaus 9, Lithuania.
Medicina (Kaunas, Lithuania)
|January 29, 2003
Summary
This study optimized Ginkgo leaf tincture production by determining the best ethanol concentration, particle size, and percolation method. The resulting tincture meets quality standards for flavonoids, heavy metals, and microbial safety.
Area of Science:
- Pharmacognosy
- Phytochemistry
- Pharmaceutical Technology
Background:
- Ginkgo biloba leaf extract is widely used in traditional and modern medicine.
- Standardized production methods are crucial for ensuring the quality and efficacy of herbal tinctures.
- Optimizing extraction parameters is key to maximizing the yield and stability of active compounds.
Purpose of the Study:
- To determine the optimal parameters for the production of Ginkgo leaf tincture.
- To establish the ideal extractant, raw material particle size, and extraction method.
- To analyze the quality and stability of the produced tincture.
Main Methods:
- Extraction of Ginkgo leaves using varying ethanol concentrations (70% V/V optimal).
- Optimization of raw material particle size (2-3 mm optimal).
- Percolation method with a controlled flow speed (0.5 ml/min optimal).
Main Results:
- Optimal extraction achieved with 70% ethanol, 2-3 mm particle size, and percolation at 0.5 ml/min.
- The tincture was analyzed for total flavonoids (quercetin equivalent), dry residue, ethanol concentration, density, refractive index, heavy metals, and microbial contamination.
- Stability studies were conducted to determine the tincture's shelf life.
Conclusions:
- The optimized production method yields a high-quality Ginkgo leaf tincture.
- The established parameters ensure consistent product quality and safety.
- The determined expiry date provides guidance for clinical use and storage.