Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hsp70 is present in human saliva.

Tibor Károly Fábián1, Judit Gáspár, László Fejérdy

  • 1Prosthetic Dentistry Clinic, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|January 29, 2003
PubMed
Summary

Heat shock protein 70 (Hsp70) is present in human saliva, indicating its secretion into this fluid. Its presence suggests passive transport mechanisms, not exocytosis, are involved in salivary Hsp70 secretion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops.

BMC biology·2026
Same author

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

MarkerPredict: predicting clinically relevant predictive biomarkers with machine learning.

NPJ systems biology and applications·2025
Same author

System level network data and models attack cancer drug resistance.

British journal of pharmacology·2025
Same author

Cancer drug resistance as learning of signaling networks.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?

Cellular and molecular life sciences : CMLS·2024

Area of Science:

  • Molecular Biology
  • Immunology
  • Biochemistry

Background:

  • Molecular chaperones, like Hsp70, are increasingly recognized for extracellular functions influencing immune responses.
  • Hsp70 is found in human blood serum, but not pancreatic juice, prompting investigation into its presence in other secretions like saliva.

Purpose of the Study:

  • To investigate the presence and secretion mechanisms of Hsp70 in human saliva.
  • To compare Hsp70 secretion with that of other salivary components like amylase.

Main Methods:

  • Human saliva samples were collected under resting and stimulated conditions.
  • Proteins were analyzed using SDS-PAGE and Western blot to detect Hsp70.
  • Salivary volume, protein concentration, and amylase activity were quantified.

Related Experiment Videos

Main Results:

  • Hsp70 was detected in the saliva of all participants.
  • Salivary stimulation significantly increased Hsp70 output, total protein, and amylase activity.
  • Hsp70/protein and Hsp70/amylase ratios decreased upon stimulation.

Conclusions:

  • Hsp70 is secreted into saliva through mechanisms distinct from the exocytotic pathway used by amylase.
  • Passive transport from blood serum or salivary gland cells are likely routes for Hsp70 secretion into saliva.