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Updated: Aug 2, 2026
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Can small animal imaging accelerate drug development?
1Johns Hopkins University School of Medicine, Department of Radiology, Baltimore, Maryland 21287-2182, USA. mpomper@jhmi.edu
Abstract:
Better mechanistic understanding of disease through mapping of the human and mouse genomes enables rethinking of human infirmity. In the case of cancer, for example, we may begin to associate disease states with their underlying genetic defects rather than with the organ system involved. That will enable more selective, nontoxic therapies in patients who are genetically predisposed to respond to them. Because one of the major goals of molecular imaging research is to interrogate gene expression noninvasively, it can impact greatly on that process. Most of molecular imaging research is undertaken in small animals, which provide a conduit between in vitro studies and human clinical imaging. We are fortunate to be able to manipulate small animals genetically, and to have increasingly better models of human disease. The ability to study those animals noninvasively and quantitatively with new, high-resolution imaging devices provides the most relevant milieu in which to find and examine new therapies.
Insights
Mapping human and mouse genomes advances disease understanding, enabling targeted therapies. Molecular imaging in animal models is key for developing these precise, non-toxic treatments for genetic diseases like cancer.
Area of Science:
- Genomics
- Molecular Imaging
- Translational Medicine
Background:
- Genomic mapping offers new insights into human diseases, shifting focus from organ systems to underlying genetic defects.
- This paradigm shift facilitates the development of more selective and less toxic therapies tailored to individual genetic predispositions.
- Molecular imaging research aims to noninvasively interrogate gene expression, playing a crucial role in this therapeutic advancement.
Purpose of the Study:
- To highlight the impact of molecular imaging research on understanding and treating genetically driven diseases.
- To emphasize the importance of small animal models in bridging in vitro studies and human clinical imaging.
- To underscore the potential of noninvasive, quantitative imaging in developing novel therapeutic strategies.
Main Methods:
- Utilizing genomic data from human and mouse populations.
- Employing molecular imaging techniques in small animal models.
- Developing and applying high-resolution imaging devices for quantitative analysis.
Main Results:
- Establishing a mechanistic understanding of diseases through genome mapping.
- Demonstrating the potential for associating disease states with specific genetic defects.
- Validating the use of small animal models for preclinical therapeutic evaluation.
Conclusions:
- Genomic understanding and molecular imaging are revolutionizing disease treatment approaches.
- Small animal models are essential for advancing molecular imaging and therapeutic development.
- Noninvasive, quantitative imaging in genetically modified animals provides a powerful platform for discovering and examining new therapies.
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