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Updated: Sep 27, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
Published on: October 20, 2023
[Formation and characteristics of an artificial dermis--collagen-chondroitin-6-sulfate membrane]
Abstract:
In this study, we extracted type-I collagen from rat tail tendon with acetic acid and then mixed it with chondroitin-6-sulfate to form a collagen-chondroitin-6-sulfate membrane by freeze drying and crosslinking. The result showed that the collagen-chondroitin-6-sulfate membrane was semitransparent, with a network structure, and the pore size was about 100-150 microns. It was also demonstrated that the "dermis" achieved a good adherence to wound and the degradation rate in vitro was markedly decreased by glutaraldehyde crosslinkage.
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