[Vroman effect of plasma protein adsorption to biomaterials surfaces]

Fibrinogen adsorption from plasma to biomaterials surfaces passes through a maximum when studied as a function of adsorption time, plasma concentration, or column height in narrow spaces and these are called Vroman effect. Studies have demonstrated that Vroman effect is a general phenomenon of plasma proteins and reflects the competitive adsorption of plasma proteins for a limited number of surface sites. In this paper, the factors affecting Vroman effect, the relationship between contact activation and fibrinogen displacement, and the significance of the Vroman effect with respect to blood-material interactions are reviewed.