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Published on: January 5, 2017
Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a
Ching Y Wang1, Richard F Jones, Maria Debiec-Rychter
1Department of Urology, SUNY Upstate Medical University, VA Medical Center, Syracuse, NY, USA. wangc@upstate.edu
Background:
The arylamine N-acetyltransferases play a major role in the metabolic activation of carcinogenic amines that are present in cigarette smoke and a variety of other exogenous sources. The objective of this study was to determine the association of rapid or slow arylamine N-acetyltransferase (NAT) genotypes with smoking history and the risk for developing both bladder and prostate cancer.
Patients And Methods:
The subjects analyzed were a case group of 17 double-cancer patients and 34 age-matched controls who had benign prostatic hypertrophy, but were asymptomatic for prostate or bladder cancers. Genotyping of NAT1 and NAT2 alleles was done by restriction fragment length polymorphism and/or sequencing of NAT genes amplified from genomic DNAs by the polymerase chain reaction (PCR).
Results:
No significant correlation was found between NAT1 genotypes, double cancer, and smoking history. While NAT2-smoking interaction gave an odds ratio of only 1.70 (p = 0.117), a disproportionate number of cancer cases were genotypically rapid: 12 of 17 cancer cases vs. 13 of 34 controls (odds ratio 3.88; p = 0.040).
Conclusion:
Rapid NAT2 genotype correlated significantly with the development of double prostate-bladder cancer.
