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Related Experiment Videos

Persistent fetal circulation: Newly recognized structural features.

S G Haworth, L Reid

    The Journal of Pediatrics
    |April 1, 1976
    PubMed
    Summary
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    Infant deaths linked to pulmonary hypertension may stem from congenital structural abnormalities in the pulmonary arteries. This study reveals abnormal muscle growth in infant lungs, suggesting a birth defect.

    Area of Science:

    • Pediatric Pathology
    • Cardiovascular Physiology
    • Neonatal Medicine

    Background:

    • Pulmonary hypertension in infants can be fatal.
    • The underlying causes of some infant pulmonary hypertension cases remain unknown.

    Purpose of the Study:

    • To investigate the structural pulmonary vascular abnormalities in infants who died from unexplained pulmonary hypertension.
    • To determine if congenital structural abnormalities contribute to persistent pulmonary hypertension of the newborn.

    Main Methods:

    • Quantitative morphologic techniques were used to examine lung tissue from three infants.
    • Analysis focused on the muscle coat thickness and extent of muscularization in intra-acinar pulmonary arteries.

    Main Results:

    Related Experiment Videos

    • All three infants exhibited increased muscle thickness in normally muscular intra-acinar pulmonary arteries.
    • Abnormal extension of muscle tissue was observed into smaller, peripheral intra-acinar arteries not typically muscular at this age.

    Conclusions:

    • The findings suggest a congenital structural abnormality of the pulmonary circulation in some cases of persistent pulmonary hypertension of the newborn.
    • This abnormality, characterized by abnormal pulmonary artery muscularization, may be present at birth.