Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal hyperuricemia.

K O Raivio

    The Journal of Pediatrics
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Neonatal hyperuricemia, indicated by high serum and urinary uric acid, is linked to increased uric acid production, not renal retention, in infants with idiopathic respiratory distress syndrome. This suggests a connection to perinatal hypoxia and nucleotide breakdown.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Erythropoietin therapy in premature infants with very low birth weight].

    Duodecim; laaketieteellinen aikakauskirja·2002
    Same author

    Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension.

    Pediatric pulmonology·2001
    Same author

    Nuclear factor Y activates the human xanthine oxidoreductase gene promoter.

    FEBS letters·2000
    Same author

    Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells.

    American journal of physiology. Lung cellular and molecular physiology·2000
    Same author

    Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.

    The Biochemical journal·2000
    Same author

    Expression of gamma-glutamylcysteine synthetase during development.

    Pediatric research·2000

    Area of Science:

    • Neonatal physiology
    • Biochemistry
    • Pediatric medicine

    Background:

    • Idiopathic respiratory distress syndrome (IRDS) is a common neonatal condition.
    • Uric acid metabolism in newborns is not fully understood.
    • Perinatal hypoxia can affect metabolic processes.

    Purpose of the Study:

    • To investigate serum and urinary uric acid levels in normal newborns and infants with IRDS.
    • To determine the cause of hyperuricemia in neonates with IRDS.
    • To provide recommendations for managing elevated uric acid levels.

    Main Methods:

    • Measurement of serum uric acid concentrations in cord blood and at various time points post-birth.
    • Quantification of urinary uric acid excretion.
    • Comparison of uric acid levels between normal neonates and those with IRDS.

    Related Experiment Videos

    Main Results:

    • Normal infants showed a transient increase in serum urate post-birth, followed by a decrease.
    • Infants with IRDS exhibited higher serum urate concentrations and increased urinary uric acid excretion.
    • A positive correlation between maximal serum urate and urinary excretion suggested increased production rather than renal retention.

    Conclusions:

    • Neonatal hyperuricemia in IRDS is likely due to increased uric acid production, possibly from elevated nucleotide breakdown associated with perinatal hypoxia.
    • Recommendations include maintaining adequate hydration, urinary flow, and urine alkalinization.
    • Further research into the link between hypoxia, nucleotide metabolism, and uric acid production in neonates is warranted.