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Updated: Aug 4, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[A novel high quality specific antithrombotic drug--hirudin]
1Department of Chemistry, Department of Polymer Materials Sichuan Union University, Chengdu 610065.
Summary
Hirudin, a potent thrombin inhibitor, is a promising antithrombotic drug in clinical trials. This review covers its properties, activity, and production methods.
Area of Science:
- Biochemistry
- Pharmacology
Context:
- Hirudin is a highly specific inhibitor of thrombin.
- Thrombin plays a critical role in the coagulation cascade.
- Antithrombotic therapies are essential for managing thrombotic disorders.
Purpose:
- To provide a comprehensive review of hirudin.
- To detail hirudin's composition, structure, and characteristics.
- To summarize methods for hirudin isolation, recombination, and synthesis.
Summary:
- Hirudin exhibits potent anticoagulant and antithrombotic activity.
- Pharmacological and pharmacokinetic profiles of hirudin are discussed.
- Various methods for obtaining hirudin, including isolation, recombinant production, and chemical synthesis, are reviewed.
Impact:
- Hirudin represents a novel therapeutic agent for antithrombotic treatment.
- Understanding hirudin's multifaceted aspects is crucial for its clinical application.
- This review consolidates key information for researchers and clinicians in the field of anticoagulation.
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