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Updated: Aug 26, 2026
Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty
Published on: February 27, 2018
Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing
Thomas Barthel1, Bernd Baumann, Ulrich Nöth
1Department of Orthopaedic Surgery, König-Ludwig-Haus, Julius Maximilians University, DE-97074 Würzburg, Germany. t-barthel.klh@mail.uni-wuerzburg.de
Abstract:
We performed a randomized, prospective study on the prophylaxis of heterotopic ossification (HO) after total hip arthroplasty (THR), comparing indomethacin and the selective COX-2 inhibitor meloxicam. From the day after surgery, 272 patients were treated with 7.5 mg meloxicam, 15 mg meloxicam, or 2 x 50 mg indomethacin a day, for 14 days. After 6 months, radiographs of patients treated with 7.5 mg meloxicam showed that HO had occurred in one third. This treatment was therefore stopped after 26 patients have been assigned to this group. According to the intention-to-treat principle, patients given 15 mg meloxicam developed HO in 25% (20% Brooker grade I, 4% grade II and 1% grade III) and those given indomethacin in 10% (7% Brooker grade I, 1% grade II and 2% grade III), a statistically significant difference.
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