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Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in
G Lombardi1, A Colao, P Marzullo
1Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy. gaelomba@unina.it
Journal of Endocrinological Investigation
|January 30, 2003
Summary
Lanreotide, a somatostatin analog, effectively reduced left ventricular mass and improved heart rhythm in acromegaly patients. This treatment also enhanced ventricular filling, offering a better cardiac profile.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Acromegaly, a condition of excess growth hormone, is associated with significant cardiovascular complications, including left ventricular hypertrophy and arrhythmias.
- Lanreotide, a long-acting somatostatin analog, is used to control growth hormone levels in acromegaly.
Purpose of the Study:
- To investigate the effects of lanreotide on left ventricular morphology, function, and the incidence of ventricular arrhythmias in patients with active acromegaly.
Main Methods:
- A prospective, multi-center study involving 19 patients with newly diagnosed acromegaly.
- Cardiac assessments using Doppler-echocardiography and 24-hour Holter ECG monitoring were performed at baseline and after 6 months of lanreotide therapy.
Main Results:
- Lanreotide treatment significantly reduced left ventricular mass and led to the regression of left ventricular hypertrophy in some patients.
- The treatment improved diastolic function, indicated by an increased E/A ratio, and reduced mean heart rate.
- A significant decrease in the prevalence of ventricular premature beats was observed, while supra-ventricular premature beats remained unaffected.
Conclusions:
- Lanreotide therapy in acromegaly patients effectively reduces left ventricular mass and improves cardiac diastolic function.
- The treatment also demonstrates a beneficial effect on the ventricular arrhythmic profile, reducing the occurrence of ventricular premature beats.