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Sevoflurane anaesthesia in chickens during spontaneous and controlled ventilation
K Naganobu1, K Ise, T Miyamoto
1Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Miyazaki 889-2192, Japan.
The Veterinary Record
|January 30, 2003
Summary
Sevoflurane affects chicken physiology, increasing carbon dioxide partial pressure (PaCO2) and heart rate during spontaneous breathing. Controlled ventilation mitigates these sevoflurane effects, reducing PaCO2 and heart rate changes.
Area of Science:
- Veterinary Anesthesia
- Avian Physiology
Background:
- Sevoflurane is a widely used inhalation anesthetic in veterinary medicine.
- Understanding its dose-dependent effects in avian species is crucial for safe anesthetic protocols.
Purpose of the Study:
- To investigate the dose-related effects of sevoflurane on cardiorespiratory parameters in chickens.
- To compare these effects during spontaneous versus controlled ventilation.
Main Methods:
- A crossover study design was employed in chickens.
- Sevoflurane was administered at end-tidal concentrations ranging from 2.2% to 4.4%.
- Cardiorespiratory variables including respiratory rate, blood gases, heart rate, and arterial blood pressure were monitored.
Main Results:
- Increasing sevoflurane concentration elevated carbon dioxide partial pressure (PaCO2) and heart rate during spontaneous ventilation.
- Controlled ventilation maintained PaCO2 within normal limits (29-42 mmHg) and prevented heart rate increases.
- Sevoflurane decreased arterial blood pressure in both ventilation modes, with a dose-dependent effect observed only during controlled ventilation.
Conclusions:
- Controlled ventilation effectively counteracts sevoflurane-induced hypercapnia and tachycardia in chickens.
- The anesthetic's hypotensive effects are more pronounced during controlled ventilation, potentially influenced by the absence of hypercapnia.