An evaluation of cefaclor in Pakistani children with pharyngotonsillitis
S J Siddiqui1, A Awan, A Ekangakic
1Eli Lilly, Indonesia.
Insights
Cefaclor effectively treated pharyngotonsillitis in Pakistani children, showing a 99% symptomatic response rate with minimal adverse events. This study confirms cefaclor
Area of Science:
- Pediatrics
- Infectious Diseases
- Pharmacology
Background:
- Pharyngotonsillitis is a common childhood infection.
- Bacterial pathogens, particularly Group A beta-hemolytic Streptococci, are frequent causes.
- Effective antibiotic treatment is crucial to prevent complications.
Purpose of the Study:
- To evaluate the efficacy and safety of cefaclor for treating pharyngotonsillitis in children.
- To assess the symptomatic response and microbiological outcomes of cefaclor treatment.
- To identify any adverse events associated with cefaclor use in this population.
Main Methods:
- A study involving Pakistani children aged 2-12 years diagnosed with pharyngotonsillitis.
- Cefaclor administered at 20-40 mg/kg/day in three divided doses for 7 days.
- Evaluation based on symptomatic improvement and bacteriological examination, including antibiotic susceptibility.
Main Results:
- A 99% symptomatic response rate (cure or improvement) was observed.
- Group A beta-hemolytic Streptococci was the most common pathogen (45%); 64% eradication achieved.
- Only 7 out of 107 patients experienced non-serious adverse events (e.g., diarrhea, rash).
Conclusions:
- Cefaclor demonstrated high efficacy with a 99% symptomatic response rate.
- The safety profile of cefaclor was favorable, with few non-serious adverse events.
- Cefaclor is an effective and safe treatment option for pharyngotonsillitis in Pakistani children.
Objective:
To assess the efficacy, safety of cefaclor for the treatment of pharyngotonsillitis in Pakistani children.
Method:
Pakistani children between the ages of two to twelve years and diagnosed with pharyngotonsillitis were eligible to participate in the study. Cefaclor was administered three times daily for a total dose of 20-40 mg/kg/day, depending on the severity of the infection, for 7 days. Patients were evaluated on the basis of symptomatic response and antibiotic susceptibility pattern as a result of bacteriological examination.
Results:
Based on observed pre-therapy signs/symptoms of infection with pharyngotonsillitis, 99% of patients (95% CI=94.9% to 100.0%) were reported as having a symptomatic response of Cure or Improvement by end of study. Group A b-haemolytic Streptococci was the most prevalent pathogen isolated pre-therapy (occurring in 45% of patients). Of all patients for whom this pathogen was isolated, 64% had complete eradication by end of therapy, while there was persistence or superinfection in 36% of patients. Only 9 occurrences of non-serious adverse events were observed among 7 of the 107 patients, including diarrhea (5), nausea (1), vomiting (1), rash (1) and stomatitis (1).
Conclusion:
Based on the high symptomatic response rate of 99% and the positive safety data, cefaclor was found to be effective and safe in treating Pakistani children with pharyngotonsillitis.
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