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Updated: Jul 10, 2026

Visualization of Surface-tethered Large DNA Molecules with a Fluorescent Protein DNA Binding Peptide
Published on: June 23, 2016
A potent, water-soluble and photoinducible DNA cross-linking agent
Ping Wang1, Renpeng Liu, Xiaojun Wu
1College of Chemistry and Molecular Sciences, Wuhan University, Hubei Wuhan 430072, P. R. of China.
Abstract:
Water-soluble DNA cross-linking phenol and biphenol derivatives 3 and 6 have been synthesized by a Mannich reaction. Both of them can cross-link DNA by photoactivation using visible light (wavelength > 400 nm). Compound 6 can cross-link DNA at pH 5.0 and 7.7, whereas no cross-link was observed at pH 10.0. Density functional theory (DFT) calculation indicated that 6 displays a twist structure. Therefore, it could bind to DNA naturally and has potent property to cross-link DNA after photoactivation.
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