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Catalytic asymmetric silane alcoholysis: practical access to chiral silanes
Darby R Schmidt1, Steven J O'Malley, James L Leighton
1Department of Chemistry, Columbia University, New York, New York 10027, USA.
Journal of the American Chemical Society
|January 30, 2003
Abstract:
A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.