Related Experiment Videos

Effects of metabolic control on vitamin E nutritional status in children with type 1 diabetes mellitus

C Campoy1, R M Baena, E Blanca

  • 1Department of Paediatrics, School of Medicine, University of Granada, Avda. de Madrid 11, Granada 18012, Spain.

Clinical Nutrition (Edinburgh, Scotland)
|January 30, 2003
PubMed

Insights

Poor metabolic control in children with insulin-dependent diabetes mellitus (IDDM) is linked to higher vitamin E levels. Despite this, vitamin E status appears maintained even with worsened diabetes control.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Metabolic Disorders

Background:

  • Insulin-dependent diabetes mellitus (IDDM) affects children's metabolic health.
  • Nutritional status, including vitamin E, can be influenced by metabolic control.
  • Understanding vitamin E dynamics in pediatric IDDM is crucial for managing long-term health.

Purpose of the Study:

  • To investigate the relationship between metabolic control in pediatric IDDM and vitamin E nutritional status.
  • To assess how different levels of glycemic control impact plasma and erythrocyte vitamin E concentrations.

Main Methods:

  • Studied 47 children with IDDM, categorized by glycosylated hemoglobin (HbA1c) levels into "good," "moderate," and "poor" control.
  • Matched with 16 healthy children for age and sex.
  • Measured serum lipids (cholesterol, triglycerides, HDLc, LDLc) and vitamin E (plasma and erythrocyte) and vitamin A (plasma).

Main Results:

  • Children with "poor" IDDM control showed significantly higher plasma vitamin E (Vit Ep) and atherogenic risk markers compared to those with "good" control.
  • Direct correlations were observed between plasma vitamin E and HbA1c levels.
  • Erythrocyte vitamin E (Vit Ee) levels remained unchanged across control groups.

Conclusions:

  • Worsening metabolic control in pediatric IDDM correlates with increased plasma vitamin E concentrations.
  • Vitamin E nutritional status appears to be maintained in children with IDDM, even with poor metabolic control.
  • These findings highlight the complex interplay between diabetes management and vitamin E levels in children.
Abstract

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...