Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitral Regurgitation I: Introduction

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monolithically integrated low linewidth comb source using gain switched slotted Fabry-Perot lasers.

Optics express·2016

Same author

Atrial fibrillation with Wolff-Parkinson-White syndrome in epilepsy: A potentially fatal combination.

Seizure·2015

Same author

Palmitoylation of nicotinic acetylcholine receptors.

Journal of molecular neuroscience : MN·2009

Same author

Comparison of ethanol septal reduction therapy with surgical myectomy for the treatment of hypertrophic obstructive cardiomyopathy.

Journal of the American College of Cardiology·2001

Same author

Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure?

Circulation·2001

Same author

Cardiac hypertrophy after transplantation is associated with persistent expression of tumor necrosis factor-alpha.

Circulation·2001

Search research articles

Related Experiment Video

Updated: Jul 21, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Diastolic compliance of the left ventricle in man.

W H Gaasch, M A Quinones, E Waisser

The American Journal of Cardiology

|August 1, 1975

Summary

Estimating left ventricular end-diastolic compliance using a single pressure-volume point is reliable. This method offers a practical alternative to the two-coordinate approach for assessing cardiac function.

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Related Experiment Videos

Last Updated: Jul 21, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Area of Science:

Cardiology
Physiology
Biomedical Engineering

Background:

Left ventricular end-diastolic pressure and volume are crucial for assessing cardiac function.
Accurate measurement of ventricular compliance is essential for understanding diastolic function and heart failure.

Purpose of the Study:

To evaluate the accuracy of a single-point method for determining left ventricular end-diastolic compliance.
To compare this method with the traditional two-coordinate approach.
To introduce a normalized index of myocardial strain.

Main Methods:

Infusion of angiotensin in 22 patients to obtain left ventricular pressure-volume data.
Calculation of end-diastolic volume compliance (dV/VdP) using the slope (k) of the ln P-V relation.
Derivation of left ventricular linear compliance and normalization for wall thickness.
Calculation of myocardial strain (muscle fiber stretch) as the product of linear compliance and end-diastolic stress.

Main Results:

Estimates of end-diastolic compliance from a single pressure-volume coordinate correlated well (r=0.90) with the two-coordinate method.
Specific compliance (deltaV/V1 deltaP) was found to be misleading in certain cardiomyopathies.
Volume compliance is influenced by operating pressure, potentially affecting compliance in ventricles of various sizes.
A novel index of myocardial strain was derived.

Conclusions:

A single pressure-volume coordinate method provides a reliable estimate of left ventricular end-diastolic compliance.
This simplified method is a practical alternative to the two-coordinate approach.
The derived myocardial strain index may offer insights into systolic performance and length-performance relations in different ventricular conditions.