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The effect of platinum-based combination chemotherapy on the lymph nodes in advanced-stage epithelial ovarian cancer:
T Simsek1, M Simsek, E Pesterelli
1Department of Obstetrics and Gynaecology, Akdeniz University School of Medicine, Antalya, Turkey. Simsek@med.akdeniz.edu.tr
Summary
Platinum-based chemotherapy did not significantly reduce lymph node metastasis in advanced ovarian cancer patients. This study examined lymphadenectomy outcomes before and after chemotherapy in epithelial ovarian carcinoma.
Area of Science:
- Gynecologic Oncology
- Medical Oncology
Background:
- Advanced-stage epithelial ovarian carcinoma often involves lymph node metastasis.
- The role of lymphadenectomy in conjunction with chemotherapy requires further investigation.
Purpose of the Study:
- To evaluate the impact of platinum-based combination chemotherapy on lymph node involvement in advanced epithelial ovarian carcinoma.
- To compare lymph node metastasis rates in patients undergoing lymphadenectomy before versus after chemotherapy.
Main Methods:
- Retrospective study of 47 advanced epithelial ovarian carcinoma patients from 1997-2000.
- Patients were divided into two groups: lymphadenectomy before chemotherapy (Group A) and after chemotherapy (Group B).
- Lymph node metastasis was assessed in both groups.
Main Results:
- Lymph node metastasis was detected in 56% of patients in Group A and 45.4% in Group B.
- The difference in lymph node metastasis rates between the two groups was not statistically significant (P > 0.05).
Conclusions:
- Platinum-based combination chemotherapy does not significantly decrease the incidence of lymph node involvement in advanced-stage epithelial ovarian carcinoma.
- The timing of lymphadenectomy relative to chemotherapy does not appear to significantly alter lymph node metastasis rates in this patient cohort.