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Optimizing formulation factors in preparing chitosan microparticles by spray-drying method.

Y-C Huang1, C-H Chiang, M-K Yeh

  • 1Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.

Journal of Microencapsulation
|January 30, 2003
PubMed
Summary
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Spray-drying successfully created chitosan microparticles for controlled betamethasone delivery. These microparticles exhibited desirable characteristics, including high drug entrapment and tunable release profiles, showing promise for pharmaceutical applications.

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Chitosan-based microparticles are investigated for drug delivery applications.
  • Controlled release formulations are crucial for optimizing therapeutic efficacy.
  • Betamethasone is a corticosteroid used to reduce inflammation and allergic reactions.

Purpose of the Study:

  • To prepare and characterize chitosan/Pluronic F68/gelatin microparticles for controlled betamethasone delivery.
  • To investigate the influence of formulation parameters and drug loading on microparticle properties and in vitro drug release.
  • To evaluate the potential of spray-drying as a method for producing these microparticulate systems.

Main Methods:

  • Microparticles were prepared using a spray-drying technique with chitosan, Pluronic F68, and gelatin.

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  • Characterization included yield rate, zeta potential, particle size, tap density, and morphology (SEM).
  • In vitro release studies were conducted to assess drug release kinetics at varying drug/polymer ratios.

    • Main Results:

    • Spray-drying yielded spherical, smooth chitosan-based microparticles with sizes ranging from 2.12-5.67 microm.
    • Betamethasone-loaded microparticles achieved high trapping efficiencies (up to 94.5%) and controlled particle sizes (4.32-6.20 microm).
    • Drug release rates were dependent on drug loading, with lower loading resulting in increased release and burst effect.

    Conclusions:

    • Spray-drying is a viable method for producing controlled-release betamethasone-loaded chitosan/Pluronic F68/gelatin microparticles.
    • Formulation parameters significantly influence microparticle characteristics and drug release profiles.
    • These microparticles demonstrate potential for effective and tunable drug delivery systems.