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Tumor necrosis factor-induced signal transduction and left ventricular remodeling
1Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, Houston Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA.
Journal of Cardiac Failure
|January 30, 2003
Abstract:
Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently, it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article will review the role of tumor necrosis factor-induced signal transduction and the process of left ventricular remodeling.