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[Homocysteine and coronary events in coronary disease patients]

P Ambrosi1, A Barlatier, A Artaud-Navarro

  • 1Service de Cardiologie B, Hôpital de la Timone, 13385 Marseille.

Annales De Cardiologie Et D'Angeiologie
|January 31, 2003
PubMed

Insights

Serum homocysteine levels in coronary heart disease patients did not predict coronary events. However, higher homocysteine predicted major adverse events, indicating its prognostic value for survival.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Medical Prognostics

Context:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable prognostic markers for CHD patients is crucial for risk stratification and management.
  • Serum homocysteine has been investigated as a potential biomarker in cardiovascular disease.

Purpose:

  • To evaluate the prognostic significance of serum homocysteine levels in patients diagnosed with coronary heart disease.
  • To determine the correlation between homocysteine levels and established CHD risk factors.
  • To assess the predictive value of homocysteine for major adverse cardiovascular events during follow-up.

Summary:

  • Serum homocysteine levels were measured in 76 CHD patients (mean age 59.2 years) undergoing hospitalization for myocardial ischemia or infarction.
  • Homocysteine showed a strong correlation with serum creatinine but not with most traditional CHD risk factors, except hypertension.
  • While not predicting all coronary events, higher homocysteine levels were observed in patients experiencing major adverse events (death, nonfatal MI, transplant). Multivariate analysis identified serum homocysteine as a significant predictor of major event-free survival (p=0.02).

Impact:

  • This study suggests that serum homocysteine, particularly when elevated, may serve as a valuable prognostic indicator for adverse outcomes in coronary heart disease patients.
  • The findings highlight the potential role of homocysteine in refining risk assessment beyond traditional factors.
  • Further research could explore therapeutic strategies targeting homocysteine to improve long-term survival in CHD populations.

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