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p53 expression in tissue adjacent to endometrial carcinoma
E B Shem1, Y Fintsi, I Avinoach
1Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, Edith Wolfson Medical Center, Holon, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
European Journal of Gynaecological Oncology
|January 31, 2003
Summary
p53 alterations may occur early in endometrial cancer development, not just late. Some tissues adjacent to tumors show p53 changes, suggesting other early events in carcinogenesis.
Area of Science:
- Oncology
- Molecular Biology
- Gynecologic Pathology
Background:
- Previous studies suggested p53 alterations are late events in endometrial carcinoma.
- The role of p53 in early endometrial carcinogenesis remained unclear.
Purpose of the Study:
- To investigate the presence of p53 in tissues adjacent to endometrial endometrioid carcinoma.
- To determine if p53 alterations are an early or late event in endometrial cancer development.
Main Methods:
- Immunohistochemical staining for p53 was performed on 49 endometrial endometrioid carcinoma specimens.
- Both tumor tissue and adjacent uninvolved endometrium were analyzed.
Main Results:
- p53 positive staining was observed in 44.9% of tumors and 16.3% of adjacent tissues.
- Hyperplastic adjacent tissues showed a significantly higher rate of p53 positivity (50.0%) compared to non-hyperplastic adjacent tissues (11.3%).
Conclusions:
- p53 alterations may not be exclusively late events in endometrial carcinogenesis.
- The presence of p53 alterations in adjacent tissues suggests potential early involvement, with other cellular events also playing a role.