Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.8K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K
Whole Body Regeneration01:33

Whole Body Regeneration

4.2K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.2K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.6K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.6K
Liver Regeneration01:24

Liver Regeneration

4.5K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.5K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oriented migration of interstitial cells and nematocytes inHydra attenuata.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen·2017
Same author

Regulation of interstitial cell differentiation inHydra attenuata : II. Correlation of the axial position of the interstitial cell with nematocyte differentiation.

Wilhelm Roux's archives of developmental biology·2017
Same author

Head regeneration and polarity reversal inHydra attenuata can occur in the absence of DNA synthesis.

Wilhelm Roux's archives of developmental biology·2017
Same author

Organizer formation in Hydra is disrupted by thalidomide treatment.

Developmental biology·2013
Same author

The head organizer in Hydra.

The International journal of developmental biology·2012
Same author

The dynamic genome of Hydra.

Nature·2010

Related Experiment Video

Updated: Mar 1, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

13.0K

Head regeneration in Hydra.

Hans R Bode1

  • 1Developmental Biology Center and Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA. hrbode@uci.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|January 31, 2003
PubMed
Summary

Hydra regeneration involves continuous axial patterning. The same genes maintain head structure and drive head regeneration, highlighting conserved developmental processes.

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Evolutionary Biology

Background:

  • Hydra, a primitive metazoan, exhibits remarkable regenerative capabilities, particularly in its head and foot.
  • Axial patterning processes are continuously active in adult Hydra to maintain organismal form.
  • Regeneration in Hydra is morphallactic, involving the reorganization of existing tissues.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying head regeneration in Hydra.
  • To determine if the genes involved in head regeneration are also active in maintaining the adult head structure.
  • To explore the relationship between axial patterning and regeneration in this model organism.

Main Methods:

  • Molecular-level gene expression analysis.

More Related Videos

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

9.1K
Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.8K

Related Experiment Videos

Last Updated: Mar 1, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

13.0K
Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

9.1K
Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.8K
  • Comparative genomics (implied).
  • Functional studies of key genes (implied).

    • Main Results:

    • Identified a conserved set of genes involved in both head regeneration and head maintenance.
    • These genes are crucial for the continuous axial patterning in adult Hydra.
    • The molecular machinery for regeneration is closely linked to the processes maintaining adult form.

    Conclusions:

    • The study reveals a shared genetic basis for regeneration and pattern maintenance in Hydra.
    • These findings suggest that regenerative processes in Hydra are extensions of normal axial patterning.
    • The identified genes have roles in axial patterning processes relevant to bilaterians, indicating evolutionary conservation.