Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid

Area of Science:

• Cardiovascular Science
• Hematology

Background:

• High blood viscosity syndrome is a complication following myocardial infarction.
• Impaired haemorheological indices contribute to cardiovascular disease progression.

Purpose of the Study:

• To investigate the effect of diquertin and ascorbic acid combination therapy on blood viscosity after myocardial infarction in a rat model.
• To assess the impact on haemorheological parameters.

Main Methods:

• A rat model of high blood viscosity syndrome was induced post-myocardial infarction.
• Rats received a 6-day therapy of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg).
• Haemorheological indices, including erythrocyte deformability, plasma fibrinogen, and erythrocyte aggregation, were measured.

Main Results:

• The combined therapy significantly improved haemorheological indices.
• A notable decrease in blood viscosity was observed.
• This reduction was primarily attributed to enhanced erythrocyte deformability and, secondarily, to reduced plasma fibrinogen and erythrocyte aggregation.

Conclusions:

• Combination therapy with diquertin and ascorbic acid demonstrates a beneficial effect on blood rheology in a post-myocardial infarction model.
• The findings suggest potential therapeutic applications for managing blood viscosity disorders.