[Experimental study on allogeneic mandible transplantation combined with basic fibroblast growth factor]

Area of Science:

• Regenerative Medicine
• Oral and Maxillofacial Surgery
• Biomaterials Science

Background:

• Mandible defects pose significant reconstructive challenges.
• Allogeneic bone transplantation is a potential solution, but often faces limitations in integration and healing.
• Enhancing vascularization and bone remodeling is crucial for successful bone graft outcomes.

Purpose of the Study:

• To investigate the efficacy of basic fibroblast growth factor (b-FGF) in promoting revascularization and bone remodeling.
• To evaluate the use of b-FGF in conjunction with allogeneic mandible transplantation for repairing defects in rabbits.

Main Methods:

• Mandible defects were created in 20 adult rabbits.
• Experimental group: allogeneic bone + local b-FGF. Control group: allogeneic bone only.
• Revascularization and bone remodeling assessed at 1 and 3 months via vascular perfusion and histology.

Main Results:

• The group treated with allogeneic bone and b-FGF exhibited superior vascularization compared to the control.
• More rapid and complete bone formation was observed in the b-FGF treated group.
• b-FGF significantly improved the healing process of allogeneic mandible transplants.

Conclusions:

• Basic fibroblast growth factor (b-FGF) effectively enhances revascularization and bone formation in allogeneic mandible transplantation.
• Allogeneic bone combined with b-FGF represents a promising biomaterial for clinical mandibular reconstruction.
• This approach offers potential for improved outcomes in treating critical-sized bone defects.