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Updated: Sep 27, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

[The new mechanisms and reversal of drug resistance]

Shin-ichi Akiyama1

  • 1Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 1, 2003
PubMed

Insights

Drug resistance in cancer chemotherapy is a major challenge. Understanding mechanisms like ABC transporters and developing reversing agents are crucial for effective cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Anticancer agent resistance is a significant barrier to successful cancer chemotherapy.
  • Mechanisms of resistance include the induction of drug efflux pumps, notably ATP-binding cassette (ABC) transporters.
  • Predictive methods using DNA microarrays and single nucleotide polymorphism (SNP) analyses are under investigation.

Purpose of the Study:

  • To address the challenge of acquired resistance to novel anticancer agents.
  • To highlight the need for clinically available reversing agents to overcome drug resistance.

Main Methods:

  • Review of recent studies on cancer drug resistance mechanisms.
  • Analysis of the role of ABC transporters in multidrug resistance.
  • Consideration of emerging predictive technologies like DNA microarrays and SNP analysis.

Main Results:

  • Elucidation of various resistance mechanisms, with a focus on ABC transporters.
  • Identification of ongoing research in predicting tumor sensitivity to anticancer drugs.
  • Observation of resistance development to the new agent ST1571.

Conclusions:

  • Tumor resistance to anticancer agents necessitates the development of effective reversing strategies.
  • The emergence of resistance to ST1571 underscores the urgent need for clinically applicable reversing agents.

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