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Protective effects of amphotericin B against spontaneous and transplantable murine tumors
Abstract:
Two tumor systems were used to test prophylactic effects of amphotericin B (AmB). When 0.5 mg AmB was given ip every 2 weeks to AKR mice beginning at 8 weeks of age, the 50% tumor incidence for spontaneous lymphoma development was delayed 2-3 months. In the second tumor system, BALB/c mice received injections of either 20 or 50 mug AmB before receiving MOPC-315-C cells sc. The mice given the low dose of AmB demonstrated a decreased tumor incidence and a reduced tumor growth rate, when compared with controls. Opposite effects were found for the group administered the high dose; tumor incidence and rate of growth were increased.
Insights
Amphotericin B (AmB) showed varied effects on tumor development in mice. Low doses delayed spontaneous lymphoma and reduced tumor growth, while high doses accelerated tumor incidence and growth.
Area of Science:
- Oncology
- Pharmacology
Background:
- Amphotericin B (AmB) is an antifungal agent.
- Its potential prophylactic effects against tumor development require investigation.
Purpose of the Study:
- To evaluate the prophylactic effects of amphotericin B (AmB) on two different tumor systems in mice.
Main Methods:
- AKR mice received intraperitoneal injections of 0.5 mg AmB every two weeks to assess spontaneous lymphoma development.
- BALB/c mice were injected with either 20 or 50 µg AmB before subcutaneous inoculation with MOPC-315-C cells.
Main Results:
- AmB administration in AKR mice delayed the 50% incidence of spontaneous lymphoma by 2-3 months.
- In BALB/c mice, low-dose AmB (20 µg) decreased tumor incidence and growth rate.
- High-dose AmB (50 µg) increased tumor incidence and growth rate compared to controls.
Conclusions:
- Amphotericin B exhibits dose-dependent effects on tumor development.
- Low-dose AmB may have prophylactic benefits against certain tumors, whereas high-dose AmB can be detrimental.