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Therapy of transplanted lymphomas.

D L Vredevoe, E F Hays

    Journal of the National Cancer Institute
    |March 1, 1976
    PubMed
    Summary

    Allogeneic cells expressing murine leukemia virus effectively inhibited lymphoma growth. This virus-mediated therapy showed promise, with protected animals developing resistance to tumor rechallenge.

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    Area of Science:

    • Oncology
    • Virology
    • Immunology

    Background:

    • Transplanted CBA lymphoma, induced by Gross virus and passaged via syngeneic cells, served as the model tumor.
    • The study investigated the therapeutic potential of allogeneic cells and cell products against this specific lymphoma.

    Purpose of the Study:

    • To determine if allogeneic cells or cell products could effectively treat a transplanted CBA lymphoma.
    • To investigate the role of murine leukemia virus (MLV) expression in the therapeutic efficacy of these allogeneic treatments.

    Main Methods:

    • Allogeneic cells and cell products were administered to animals bearing the transplanted CBA lymphoma.
    • Virus expression in effective therapeutic agents was assessed using the XC cell in vitro infectivity assay.
    • Oncogenicity in vivo was also used to assay for virus expression in some materials.

    Main Results:

    • Allogeneic cells or products that curtailed lymphoma growth expressed MLV, confirmed by in vitro and in vivo assays.
    • Therapeutic effects were not observed with allogeneic materials lacking these viral activities.
    • Syngeneic lymphoma cells were ineffective as a therapeutic agent.

    Conclusions:

    • Murine leukemia virus expression in allogeneic cells or products is crucial for the observed therapeutic effect against transplanted CBA lymphoma.
    • This virus-mediated immunotherapy suggests a potential strategy for cancer treatment.
    • Immunity developed in protected animals, indicated by resistance to subsequent tumor rechallenge.

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