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Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Bacteraemia in children

Madhu Sharma1, Nidhi Goel, Uma Chaudhary

  • 1Department of Microbiology, Pt. B.D. Sharma, Postgraduate Institute of Medical Sciences, Rohtak, India.

Indian Journal of Pediatrics
|February 1, 2003
PubMed

Insights

Gram-negative bacteria, particularly Klebsiella, were the primary cause of bloodstream infections (bacteremia) in children. Sulbactam/cefoperazone showed high sensitivity against these multidrug-resistant organisms.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Bacteremia in children poses a significant health risk, necessitating understanding of causative agents and their antibiotic susceptibility.
  • Sepsis in pediatric populations requires prompt diagnosis and effective antimicrobial treatment.

Purpose of the Study:

  • To determine the etiology of bacteremia in children aged 0 days to 14 years.
  • To analyze the antibiotic sensitivity patterns of bacterial isolates from pediatric bloodstream infections.

Main Methods:

  • Blood cultures were performed on 4,368 children suspected of fever and sepsis over 13 months.
  • Bacterial isolates were identified using conventional methods.
  • Antibiotic susceptibility testing was conducted using the modified Stokes method.

Main Results:

  • 1,001 cases (22.9%) yielded positive blood cultures, with a 33.94% incidence in neonates.
  • Gram-negative organisms predominated (88.8%), with Klebsiella (47.1%) being the most common, followed by Salmonella sp. and Pseudomonas.
  • Sulbactam/cefoperazone demonstrated high efficacy (98.2%) against all isolates, while linezolid was most effective for Gram-positive isolates (99.0%).

Conclusions:

  • Gram-negative multidrug-resistant organisms are the leading cause of pediatric septicemia.
  • Careful selection of antibiotic therapy is crucial for managing pediatric bacteremia.
Abstract

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