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Related Experiment Videos

Steroid resistant nephrotic syndrome.

Sushmita Banerjee1

  • 1Department of Pediatrics, Calcutta Medical Research Institute, Kolkata, India. asban@vsnl.com

Indian Journal of Pediatrics
|February 1, 2003
PubMed
Summary
This summary is machine-generated.

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Steroid Resistant-Nephrotic Syndrome (NS) is a chronic kidney disease in children. Aggressive therapies improve remission rates, but further studies are needed for optimal treatment strategies.

Area of Science:

  • Pediatric Nephrology
  • Chronic Kidney Disease
  • Steroid Resistant-Nephrotic Syndrome

Background:

  • Steroid Resistant-Nephrotic Syndrome (NS) affects up to 10% of children with NS, causing significant morbidity and mortality.
  • Historically, progression to renal failure was considered inevitable in survivors of childhood NS.
  • Recent advances have identified key genes and proteins involved in NS pathogenesis.

Purpose of the Study:

  • To review current understanding and treatment of Steroid Resistant-Nephrotic Syndrome in children.
  • To highlight the impact of recent genetic and protein insights on disease pathogenesis.
  • To evaluate the efficacy of current therapeutic strategies and identify areas for future research.

Main Methods:

  • Review of recent literature on Steroid Resistant-Nephrotic Syndrome.

Related Experiment Videos

  • Analysis of studies investigating genetic and protein markers.
  • Evaluation of treatment outcomes from aggressive combination therapies and supportive agents.

    • Main Results:

    • Aggressive long-term therapies combining steroids, alkylating agents, and cyclosporine achieve complete or partial remission in 20-80% of pediatric patients.
    • Nonspecific renal protective agents, including ACE inhibitors, ARBs, and lipid-lowering drugs, help slow disease progression.
    • Significant improvements in patient outcomes are evident, though not universally achieved.

    Conclusions:

    • Current aggressive treatment regimens offer substantial benefits for children with Steroid Resistant-Nephrotic Syndrome.
    • Supportive therapies play a crucial role in retarding disease progression and managing complications.
    • Further multicenter controlled studies are essential to establish optimal drug choices and treatment protocols for improved long-term outcomes.