Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diaryloxyacetate herbicides.

Michael G Smith1, William C Lo, Wendy Jacks

  • 1Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, USA.

Pest Management Science
|February 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proximity measurements for objective assessments of crew cohesion in an antarctic space analog environment.

Frontiers in psychology·2026
Same author

The efficacy of pink noise and earplugs for mitigating sleep disruption induced by different environmental noise sources.

Sleep health·2026
Same author

Auditory and non-auditory effects of noise on health: updated evidence and future directions.

Environmental research·2026
Same author

Developing an Intergenerational Model of Structural Racism Exposure among Women in Black Families in South Carolina, 1989-2020.

Journal of racial and ethnic health disparities·2026
Same author

Workshop report: Improving standardisation of rabies serology methods and procedures.

Vaccine·2026
Same author

Evaluation of patient experiences with contraceptive counseling during the South Carolina Choose Well contraceptive access initiative.

Contraception·2026

Researchers discovered novel herbicides but faced challenges with stability limiting efficacy. Analogs were designed with improved post-emergence activity, though commercial success was not achieved due to insufficient crop selectivity.

Area of Science:

  • Agricultural Chemistry
  • Plant Science
  • Organic Chemistry

Background:

  • Novel herbicides are crucial for effective weed management in agriculture.
  • Diaryl acetal compounds represent a potential new class of herbicidal agents.
  • Understanding structure-activity relationships is key to developing potent and selective herbicides.

Purpose of the Study:

  • To discover and characterize a new family of herbicides based on a diaryl acetal structure.
  • To investigate the factors limiting the efficacy of these novel herbicides.
  • To design and synthesize analogs with enhanced herbicidal activity and selectivity.

Main Methods:

  • Chemical synthesis of diaryl acetal derivatives.
  • Evaluation of herbicidal efficacy through post-emergence bioassays.

Related Experiment Videos

  • In vitro enzyme inhibition assays targeting acetolactate synthase.
  • Structure-activity relationship analysis to guide analog design.

    • Main Results:

    • A novel family of herbicides containing a diaryl acetal moiety was identified.
    • Acetal stability was found to be a limiting factor for herbicidal efficacy.
    • Analogs were developed exhibiting commercial-level post-emergence activity against broadleaf weeds.
    • Compounds demonstrated inhibition of acetolactate synthase.
    • No analogs achieved a commercially viable balance of herbicidal efficacy and crop selectivity.

    Conclusions:

    • Diaryl acetal herbicides show promise but require optimization for stability and selectivity.
    • Acetolactate synthase inhibition is a viable mode of action for this chemical class.
    • Further research is needed to overcome limitations and achieve commercial viability for diaryl acetal herbicides.