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Long-term ex vivo bovine experiments with the Gyro C1E3 centrifugal blood pump
Shinji Kawahito1, Tomohiro Maeda, Tadashi Motomura
1Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Insights
The new Gyro C1E3 centrifugal blood pump shows stable performance for long-term extracorporeal membrane oxygenation (ECMO). This advanced pump demonstrated excellent durability and biocompatibility in extensive ex vivo calf studies.
Area of Science:
- Biomedical Engineering
- Cardiovascular Technology
- Medical Device Development
Background:
- Centrifugal blood pumps are crucial for cardiopulmonary bypass, ventricular assist, and ECMO.
- Current centrifugal pumps lack suitability for long-term ECMO applications.
- The Gyro C1E3 pump was developed to address these limitations.
Purpose of the Study:
- To evaluate the long-term durability and performance of the Gyro C1E3 centrifugal blood pump.
- To assess the antithrombogenic and antitraumatic properties of the Gyro C1E3 during simulated ECMO.
- To compare the Gyro C1E3's performance against conventional centrifugal blood pumps.
Main Methods:
- Five ex vivo long-term durability tests were conducted using healthy miniature calves.
- The Gyro C1E3 pump was integrated into an ECMO circuit with a prototype oxygenator.
- Blood was drained from the jugular vein and returned to the carotid artery for 7–15 days at 1 L/min flow rate.
Main Results:
- The Gyro C1E3 demonstrated stable performance throughout the experiments without pump replacement.
- No abnormal calf signs or blood data were observed.
- Necropsy revealed no clot, thrombus, or organ infarction, indicating superior biocompatibility.
Conclusions:
- The Gyro C1E3 centrifugal blood pump exhibits stable and reliable performance for long-term ex vivo ECMO.
- The pump's antithrombogenic and antitraumatic features are advantageous for extended use.
- The Gyro C1E3 shows significant promise for future long-term ECMO applications.
Abstract:
Centrifugal blood pumps are used widely for cardiopulmonary bypass, as ventricular assist devices, and for extracorporeal membrane oxygenation (ECMO). However, there is no centrifugal blood pump that is suitable for long-term ECMO. The authors developed the Gyro C1E3 centrifugal blood pump (Kyocera Corporation, Kyoto, Japan), which has superior antithrombogenic, antitraumatic, and hydraulic features in comparison with the conventional centrifugal blood pumps. Five ex vivo long-term durability tests of the Gyro C1E3 were performed using healthy miniature calves. The ECMO circuit was composed of a prototype hollow fiber silicone membrane oxygenator and a Gyro C1E3 pump. Venous blood was drained from the left jugular vein of a calf, passed through the oxygenator and infused into the left carotid artery using a Gyro C1E3. Ex vivo studies were performed from 7 to 15 days at a blood flow rate of 1 L/min. During this period, the Gyro C1E3 demonstrated a stable performance without exchanging the pump. Bleeding complications were the major reason for termination of each experiment. Rotational speed was maintained around 2,000 rpm. All five calves demonstrated neither abnormal signs nor abnormal blood examination data throughout the experiment. Neither clot nor thrombus formations were found during the necropsy in the cannula or pump nor were infarctions observed in any of the major organs. In conclusion, the Gyro C1E3 showed a stable and reliable performance during long-term ex vivo bovine experiments under the conditions tested.