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Updated: Aug 7, 2026
14:49
Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Complementary DNA sequence of the HLA-B*3924 allele
E Estefanía1, N Gómez-Lozano, R de Pablo
1Servicio de Immunología, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Abstract:
We have isolated the complete coding region of HLA-B*39 from a Spanish Caucasoid, using a new PCR primer for its 5' untranslated region. The cDNA matched partial genomic sequences of B*3924, an allele whose distribution appears to be restricted to Mediterranean and Arabian Caucasoids. A single amino acid change exclusive to B*3924 (threonine-98) distinguishes it from B*3903.
Related Concept Videos
01:44Complementary DNA
Overview
02:32Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...