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Effect of anatomic, procedural, and dosimetric variables on urinary retention after permanent iodine-125 prostate
Mohamed A Elshaikh1, Kenneth Angermeier, James C Ulchaker
1Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Objectives:
To correlate anatomic, procedural, and dosimetric parameters with the rate of intermittent self-catheterization (ISC).
Methods:
The records of 402 patients with a median age of 69 years treated with 125I prostate seed implantation from 1996 to 2001 were reviewed for the use of ISC. The records were examined for the preimplant factors: prostate volume, use of androgen deprivation, and prostate length. The intraprocedural factor reviewed was the number of needles used. The following postimplant information was also collected: preimplant transrectal ultrasound-generated prostate volume/postimplant computed tomography-generated prostate volume ratio, V100, V150, V200, V300, V400, D90, and D100. Correlation was assessed using logistic regression analysis.
Results:
Forty-four patients had to use ISC (10.9%). The mean and median duration of ISC was 11.9 and 6 weeks, respectively. From univariate analysis, prostate length and prostate volume were found to be statistically significant predictors of ISC after 125I prostate seed implantation with a P value of 0.0002 and 0.0042, respectively. With multivariate analysis, only prostate length was a statistically significant predictor of ISC use after 125I prostate seed implantation (P = 0.0095).
Conclusions:
Prostate length is an important predictor of ISC after 125I prostate seed implantation.