Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single molecule fluorescence and force microscopy.

G J Schütz1, P Hinterdorfer

  • 1Institute for Biophysics, University of Linz, Altenbergerstr. 69, A-4040 Linz, Austria. gerhard.schuetz@jku.at

Experimental Gerontology
|February 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-dimensional localization microscopy using deep learning.

Optics express·2019
Same author

Glycan distribution and density in native skin's stratum corneum.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2018
Same author

Single molecule binding dynamics measured with atomic force microscopy.

Ultramicroscopy·2014
Same author

Calibrated complex impedance and permittivity measurements with scanning microwave microscopy.

Nanotechnology·2014
Same author

A single-molecule approach to explore binding, uptake and transport of cancer cell targeting nanotubes.

Nanotechnology·2014
Same author

Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique.

Journal of physics. Condensed matter : an Institute of Physics journal·2012
Same journal

Astragalus membranaceus and Salvia miltiorrhiza injections confer cardioprotection via SERCA/SIRT1-mediated Ca<sup>2+</sup> regulation.

Experimental gerontology·2026
Same journal

Ayurvedic nutraceutical, Chyawanprash, enhances longevity and stress resilience via mitochondrial and muscular health in C. elegans model of ageing.

Experimental gerontology·2026
Same journal

Activation of Sirt3 reprograms mitochondrial function to regenerate intervertebral disc degeneration.

Experimental gerontology·2026
Same journal

Sit-to-stand power shows greater magnitude associations with radial bone strength compared to handgrip strength in adults aged 60-95 years: A cross-sectional study.

Experimental gerontology·2026
Same journal

Impact of simultaneous motor-cognitive training on motor capacities in older adults: A quasi-randomized parallel controlled trial.

Experimental gerontology·2026
Same journal

Triglyceride-glucose-related metabolic indices, phenotypic aging, and incident pulmonary embolism.

Experimental gerontology·2026
See all related articles

Single-molecule microscopy reveals complex biomolecular dynamics and cellular organization. This ultra-sensitive technique offers new insights into living cells and molecular processes.

Area of Science:

  • Biophysics
  • Cell Biology
  • Microscopy

Background:

  • Biomolecular studies are advancing with single-molecule analysis.
  • Molecules exhibit complex dynamics, with correlated spatial and temporal transitions.
  • Single-molecule techniques provide novel information on biomolecular samples.

Purpose of the Study:

  • To describe single-molecule microscopy methodologies.
  • To highlight their application in in vivo detection and visualization.
  • To demonstrate their utility in studying cellular processes.

Main Methods:

  • Development of sensitive microscopy techniques for single-molecule detection.
  • Application of these methods for in vivo imaging on surfaces, membranes, and cells.

Related Experiment Videos

Main Results:

  • Single-molecule microscopy provides new insights into biomolecular dynamics.
  • Visualization of molecular processes on cell membranes and within cells.
  • Revealed new understanding of plasma membrane lateral organization.

Conclusions:

  • Single-molecule microscopy is a powerful tool for biological research.
  • It offers an ultra-sensitive method to study local processes and heterogeneities in living cells.
  • Enables unprecedented visualization of molecular behavior in vivo.