The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation
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Seung-Woo Han1, Jin Tae, Jin-A Kim
1Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea.
Background:
Solanum melongena L. (Solanaceae) has antioxidant, analgesic, hypolipidemic and antiallergic activity.
Methods:
The anti-inflammatory effects of the water extract of the S. melongena (SMWE) were investigated in PAR2-mediated mouse paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw of mice. The SMWE (1, 5, 10, and 100 mg/kg) was orally administered 1 h before induction of inflammation.
Results:
At doses of 5, 10, and 100 mg/kg, the SMWE showed significant inhibition of both paw edema and vascular permeability. The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue.
Conclusion:
These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema.