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Establishment of age-dependent reference values for IgA subclasses.

Uwe Schauer¹, Frank Stemberg, Christian H L Rieger

¹Klinik für Kinder-und Jugendmedizin der Ruhr Universität Bochum, St Josef-Hospital, Alexandrinenstr 5, D-44791 Bochum, Germany. uwe.schauer@ruhr-uni-bochum.de

Clinica Chimica Acta; International Journal of Clinical Chemistry

|February 1, 2003

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This study establishes age-dependent reference values for Immunoglobulin A (IgA) subclasses in children and adults. These findings aid in reassessing IgA

Area of Science:

Immunology
Clinical Chemistry

Background:

Introduction of subclass-specific antisera for nephelometric assays.
Need for age-dependent reference values for IgA subclasses.

Purpose of the Study:

To establish age-dependent reference values for serum concentrations of IgA1 and IgA2 subclasses.
To evaluate the utility of automated immunonephelometry for IgA subclass measurement.

Main Methods:

Serum levels of IgA1 and IgA2 measured using automated immunonephelometry.
Samples analyzed from 235 healthy children (6 months-18 years) and 36 healthy adults.

Main Results:

Both IgA1 and IgA2 increased with age in children and adults.
Adult mean values: IgA1 1.46 g/l, IgA2 0.21 g/l, total IgA 1.94 g/l.

Related Experiment Videos

Significant correlations found between IgA1 and IgA2, and between total IgA and the sum of subclasses.

Conclusions:

Established age-dependent reference values for IgA subclasses.
Suggests immunonephelometry with specific antisera may be superior to other methods.
Highlights the potential to reassess the role of IgA subclasses in immunodeficiency and autoimmune diseases.