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Effectiveness of chromium in atypical depression: a placebo-controlled trial
Jonathan R T Davidson1, Kurian Abraham, Kathryn M Connor
1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Background:
Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression.
Methods:
A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) for 8 weeks.
Results:
Seven (70%) CP and zero (0%) PBO patients met responder criteria (p =.02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated.
Conclusions:
Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.