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Systolic blood pressure is the main etiology for poorly controlled hypertension
Muhammad G Alam1, Yousri M Barri
1Division of Nephrology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA. alammuhammad@uams.edu
Insights
Isolated systolic hypertension is the main cause of uncontrolled high blood pressure. Current medications are less effective at managing systolic hypertension, indicating a need for better treatments.
Area of Science:
- Cardiology
- Hypertension Research
- Pharmacology
Background:
- Isolated systolic hypertension is a significant risk factor for cardiovascular events.
- Uncontrolled hypertension poses a substantial threat to patient health.
- Effective management of isolated systolic hypertension is crucial for preventing adverse outcomes.
Purpose of the Study:
- To determine the prevalence of uncontrolled isolated systolic hypertension.
- To evaluate the effectiveness of current antihypertensive medications in treating this condition.
Main Methods:
- A retrospective chart review was conducted on 585 patients with hypertension.
- Blood pressure readings and medication data were extracted for analysis.
Main Results:
- 58% of patients had controlled blood pressure.
- Among patients with uncontrolled hypertension, 77.1% had isolated systolic hypertension.
- Patients with uncontrolled systolic hypertension were taking more antihypertensive medications on average.
Conclusions:
- Systolic hypertension is the primary driver of uncontrolled hypertension in most patients.
- Existing antihypertensive drugs show limited efficacy in controlling systolic hypertension.
- Further research into novel therapeutic strategies is warranted.
Background:
Isolated systolic hypertension is an important risk factor for cardiovascular events. The purpose of this study was to detect the prevalence of and to evaluate the effectiveness of currently available medications in the treatment of uncontrolled isolated systolic hypertension.
Methods:
We randomly selected a total of 585 patients with hypertension from our database. The two most recent blood pressure (BP) readings and other data were obtained by chart review.
Results:
Of 585 patients, 340 (58%) had controlled BP. Of 245 patients with uncontrolled hypertension, 77.1% had uncontrolled isolated systolic hypertension and the remaining 22.9% had uncontrolled diastolic hypertension. Patients with uncontrolled systolic hypertension were on average taking more antihypertensive medications than patients with controlled BP (2.10 +/- 0.09; P = .034).
Conclusions:
Systolic hypertension is the etiology of uncontrolled hypertension in the majority of patients. Currently available antihypertensive medications are less effective in controlling systolic hypertension.