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A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network
Dabeeru C Rao1, Michael A Province, Mark F Leppert
1Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA. rao@wubios.wustl.edu
American Journal of Hypertension
|February 1, 2003
Abstract:
Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.