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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides
Andreas Weihofen1, Bruno Martoglio
1Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), ETH-Hoenggerberg, 8093 Zurich, Switzerland.
Trends in Cell Biology
|February 1, 2003
Abstract:
This review summarizes recent findings and common principles for intramembrane-cleaving proteases that catalyse critical steps in cell regulation and signalling and which are involved in diseases such as Alzheimer's disease and hepatitis C virus infection.