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Updated: Sep 27, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
Lie-Chwen Lin1, Ling-Ling Yang, Cheng-Jen Chou
1National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC. lclin@cma23.nricm.edu.tw
Abstract:
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
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