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Aggression-associated changes in murine olfactory tubercle bioamines.

David R Garris1

  • 1Division of Cell Biology and Biophysics, Schools of Biological Science and Medicine, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110-2499, USA. garrisd@umkc.edu

Brain Research
|February 1, 2003
PubMed
Summary
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Aggressive behavior in mice is linked to specific brain chemical changes. Isolation-induced aggression showed altered norepinephrine and dopamine in the olfactory tubercle, while olfactory bulb removal increased serotonin in the same region.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Animal Models

Background:

  • Intraspecies aggression is a complex behavior influenced by neurobiological factors.
  • Brain bioamine levels, including norepinephrine, dopamine, and serotonin, are implicated in regulating social behaviors.
  • Understanding the neurochemical underpinnings of aggression can provide insights into social behavior regulation.

Purpose of the Study:

  • To investigate the relationship between regional brain bioamine levels and intraspecies aggressive behavior in two distinct murine models.
  • To identify specific alterations in norepinephrine, dopamine, and serotonin concentrations associated with different types of aggression.

Main Methods:

  • Two murine models of aggression were used: isolation-induced aggression and experimentally-induced aggression via olfactory bulbectomy (Obx).

Related Experiment Videos

  • High-performance liquid chromatography (HPLC) was employed to quantify norepinephrine (NE), dopamine (DA), and serotonin (5-HT) levels in the olfactory tubercle (OT) and hypothalamus (HYPOTH).
  • Behavioral assessments were correlated with neurochemical measurements in aggregated (control) and aggressive (isolated or Obx) groups.

    • Main Results:

    • Isolation-induced aggressive mice exhibited elevated NE and decreased DA in the OT compared to aggregated controls.
    • Olfactory bulbectomized (Obx) mice showed increased 5-HT in the OT compared to sham-operated controls.
    • No significant changes in hypothalamic bioamine levels were observed in either model relative to controls.

    Conclusions:

    • Distinct types of intraspecies aggressive behavior in mice are associated with specific alterations in regional bioamine levels within the olfactory tubercle.
    • These findings suggest a causal relationship between identified changes in forebrain bioamine concentrations and the manifestation of specific aggressive behaviors.
    • The olfactory tubercle appears to be a critical neural locus for processing social information and mediating aggressive responses.