Related Experiment Video
Updated: Sep 27, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
The complete genomic sequence of hepatitis delta virus genotype IIb prevalent in Okinawa, Japan
Shao-Ping Ma1,2, Hiroshi Sakugawa3, Yoshihiro Makino4,2
1Department of Virology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
Abstract:
The Miyako Islands, located in the southernmost part of Japan, have been reported to be endemic for hepatitis delta virus (HDV). The majority of HDV patients in this area exhibit a relatively mild course of infection that evolves into a quiescent cirrhotic condition. The entire nucleotide sequence of the Miyako isolate (L215) of HDV obtained from a cirrhotic patient infected with HDV was determined. This isolate, L215, comprises 1682 nt and encodes 213 aa of the hepatitis delta antigen. Phylogenetic analysis showed that L215 is closely related to the Taiwanese genotype IIb HDV isolate. In addition, the predicted folding structure of the antigenomic RNA substrate was different from those of the published genotype II sequences.
Related Concept Videos
Viral Hepatitis I: Introduction
Hepatitis
Human Virome
Viruses with RNA Genomes
Bacteriophages of the Human Virome
Inhibitors Of Virion Release

