[Coronary atherosclerosis and blood groups of ABO system in women (own data and review)]
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Donatas Stakisaitis1, Arūnas Maksvytis, Rimantas Benetis
1Klaipeda Seamen's Hospital, Liepojos 45, 5809 Klaipeda, Lithuania. arumax@takas.lt
Insights
Blood group B is linked to coronary atherosclerosis in women, while blood group O may offer protection against this condition. These findings highlight potential genetic markers for cardiovascular disease risk in women.
Area of Science:
- Cardiovascular Genetics
- Hematology
- Epidemiology
Background:
- Previous research indicated a higher prevalence of blood group B and a lower prevalence of blood group O in men under 45 with coronary atherosclerosis.
- Understanding the association between ABO blood groups and coronary atherosclerosis in women is crucial for risk stratification.
Purpose of the Study:
- To investigate the frequency of ABO blood groups in women diagnosed with coronary atherosclerosis.
- To compare these frequencies with healthy blood donors and a cohort of long-living individuals.
Main Methods:
- Analysis of ABO blood group frequencies in 441 women with coronary atherosclerosis, stratified by age (<60 and >60 years).
- Diagnosis of coronary atherosclerosis confirmed by coronary angiography and coronary bypass surgery.
- Comparison with ABO blood group frequencies in 595 healthy blood donors and 75 long-living women.
Main Results:
- Blood group O was significantly less frequent in women under 60 with coronary atherosclerosis compared to healthy donors (28.4% vs 38.2%).
- Blood group B was significantly more frequent in women over 60 with coronary atherosclerosis compared to healthy donors (22.9% vs 15.0%).
- Blood group B was less frequent in long-livers than in healthy donors and the patient groups.
Conclusions:
- Blood group B may be associated with an increased risk of coronary atherosclerosis in women.
- Blood group O might act as a protective factor against atherosclerosis in women.
- Long-living individuals serve as a valuable control group for identifying atheroprotective genetic markers.
Unlabelled:
Earlier we have shown significantly more frequent B blood group and a significantly more rare O blood group of ABO blood group system in men aged under 45 years suffering from coronary atherosclerosis compared with these frequencies in the population of Lithuania. The aim of the study was to investigate the frequency of blood groups of ABO system in women with coronary atherosclerosis.
Materials:
The frequency of the ABO blood groups was examined in 441 women, suffering from coronary atherosclerosis, divided into two groups: I group - 109 women till 60 years old (mean age 55.1+/-4.8) and II group - 332 women aged over 60 years (mean age 68.1+/-5.0). For all patients coronary atherosclerosis was diagnosed by coronary angiography and confirmed during coronary bypass surgery. The frequency of the ABO blood group in the studied pts was compared with the frequency of the blood group in the control group of healthy blood donors (n=595). To evaluate the significance of data, we compared the frequency of ABO blood groups with the data in women long-livers (n=75, mean age 94.1+/-3.8). Earlier our studies showed that long-livers are an important antiatherosclerotic control group for evaluation of the genetic markers of atherosclerosis.
Results:
The O blood group was found significantly more rarely in the women group I as compared to that of healthy donors group (28.4% vs 38.2%, p<0.04). The B blood group was significantly more often in group II (22.9% vs 15.0%, p<0.04) compared with the frequency of the B blood group in the healthy donors' group. In the long-livers' group the frequency of the B group was significantly more rare than in healthy donors (6.7% vs 15%, p<0.01) as well as in the groups of tested pts (20.2% and 22.9% respectively, p<0.01). We did not find any significant changes in the frequency of AB blood group in women with coronary atherosclerosis.
Conclusions:
The B blood group can be related with coronary atherosclerosis in women. The O blood group can possibly serve as a protective antiatherogenic factor in women. The A blood group is not a risk factor for atherosclerosis in women in Lithuanian population. Long-livers are an important antiatherogenic control group for evaluation of atherogenetic markers of coronary atherosclerosis.
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