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Topical rose bengal: pre-clinical evaluation of pharmacokinetics and safety
Eric Wachter1, Craig Dees, Jay Harkins
1Provectus Pharmaceuticals, Inc., Knoxville, Tennessee 37931, USA. wachter@provectuscorp.com
Lasers in Surgery and Medicine
|February 1, 2003
Abstract
Background And Objectives:
Rose bengal (RB) is a potent photosensitizer that has largely been overlooked as a potential photodynamic therapy (PDT) agent. In this study, the feasibility of topical delivery of RB to the epidermis has been evaluated.
Study Design/Materials And Methods:
Topical formulations of RB were assessed on murine and rabbit skin for pharmacokinetic properties, cutaneous toxicity, and photosensitization.
Results:
Hydrophilic formulations (
Conclusions:
These results indicate that RB is safe for PDT treatment of skin disorders, exhibiting negligible effects in normal skin.