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[Anticoagulant, fibrinolytic and antithrombotic effects of the heparin-insulin complex]

L A Liapina1, V E Pastorova

  • 1Biology Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.

Izvestiia Akademii Nauk. Seriia Biologicheskaia
|February 4, 2003
PubMed

Formation of heparin-insulin complex at the 1:10 molar ratio of the components has been demonstrated by spectral methods. The derived complex had anticoagulant, antithrombotic, and fibrinolytic properties of non-enzymatic nature in vitro. Intravenous injection of the complex in the animals (rats) increased anticoagulant and fibrinolytic background and at the same time decreased the plasma coagulation factors fibrinogen and factor XIIIa in the bloodstream. We propose the heparin-insulin complex as a promising antithrombotic drug.

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